British Air Force Typhoon FGR4s have operated alongside French warplanes in a joint strike against an underground arms cache in Syria operated by the IS group, as stated by the UK's MoD.
The facility, identified by intelligence, was believed to be containing munitions and bombs, the statement said, and was located in mountains just north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets employed Paveway IV guided bombs to hit a number of entry passages down to the facility... preliminary assessments suggest the target was engaged successfully," officials stated.
There was no evidence of any civilian impact in the strike late on Saturday and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
Daesh - referred to as the so-called Islamic State - imposed militant control over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates our UK leadership, and resolve to operate in unison with our partners, to eliminate any resurgence of the terrorist group and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the minister remarked.
British military aircraft have performed overwatch operations over Syria to "prevent any attempted comeback" of Islamic State after its military defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank all the members of our armed forces involved in this mission for their expertise and their valour," the Defence Secretary said. "They were among numerous British personnel stationed over Christmas and New Year. This action, to remove militants who pose a risk to our way of life, highlights how UK forces are prepared to act, all year round, protecting the UK domestically and powerful internationally."
During December, the American forces conducted what it called a "large-scale strike" against Daesh sites in Syria, after an ambush claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The UN reports IS still has roughly 5-7 thousand militants in Syria and Iraq.